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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c84cd3b3adaec5c82d07c5aaeee2680dceda7256069a5f7430907d0da968e0a' 
  AND token = 'O/wpCOhGVDnU2bVlSy0VuyWqCkDFKWXU8LFLbu3pYZA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}