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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f2e8a80d29260592b109d9006ad63dfd3a0f0e379584637ffc1618984506188' 
  AND token = 'sdgskO3HWjnJsXTBVYm7Prlo+PklCewPvPF4KkAnr2s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}