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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '740ba5423db93e967d951b73f4f7869106f78963fb18adc9dce081253e5881a7' 
  AND token = 'JVURPJXivECS0JEXVU7WWFXnvgUOwwwZnRJ6wRwV3Jc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}