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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '147fa75d0450c22b8418353cafa1ca21b2abddb8e3712bb2de846f6bff8f913d' 
  AND token = 'pGG+tVrvy7K4QMQs1anN9aAizhK1TUtytt3dvpmx53U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}