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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '221fdcc8b9d84eb6e4cf12b7a3b9acbbf43376ac27b6f37b8aed793526b59194' 
  AND token = 'oeRqYcG4rbUaWvaU36yVciv0udzBZ7xzvz0qiBhRBEM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00061

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}